Focused Ultrasound Modulates the Level of Cortical Neurotransmitters: Potential as a New Functional Brain Mapping Technique
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Byoung-Kyong | - |
dc.contributor.author | Yang, Po Song | - |
dc.contributor.author | Bohlke, Mark | - |
dc.contributor.author | Park, Shinsuk | - |
dc.contributor.author | Vago, David R. | - |
dc.contributor.author | Maher, Timothy J. | - |
dc.contributor.author | Yoo, Seung-Schik | - |
dc.date.accessioned | 2021-09-07T21:28:48Z | - |
dc.date.available | 2021-09-07T21:28:48Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0899-9457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114939 | - |
dc.description.abstract | Regional modulation of the level of cortical neurotransmitters in the brain would serve as a new functional brain mapping technique to interrogate the neurochemical actions of the brain. We investigated the utility of the application of low-intensity, pulsed sonication of focused ultrasound (FUS) to the brain to modulate the extracellular level of dopamine (DA) and serotonin (5-HT). FUS was delivered to the thalamic areas of rats, and extracellular DA and 5-HT were sampled from the frontal lobe using the microdialysis technique. The concentration changes of the sampled DA and 5-HT were measured through high-performance liquid chromatography. We observed a significant increase of the extracellular concentrations of DA and 5-HT in the FUS-treated group as compared with those in the unsonicated group. Our results provide the first direct evidence that FUS sonication alters the level of extracellular concentration of these monoamine neurotransmitters and has a potential modulatory effect on their local release, uptake, or degradation. Our findings suggest that the pulsed application of FUS offers new perspectives for a possible noninvasive modulation of neurotransmitters and may have diagnostic as well as therapeutic implications for DA/5-HT-mediated neurological and psychiatric disorders. (C) 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 232-240, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ima.20284 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TRANSCRANIAL MAGNETIC STIMULATION | - |
dc.subject | MEDIATED INHIBITION | - |
dc.subject | DOPAMINE RELEASE | - |
dc.subject | CHLORAL HYDRATE | - |
dc.subject | IN-VIVO | - |
dc.subject | SEROTONIN | - |
dc.subject | TRYPTOPHAN | - |
dc.subject | DORSAL | - |
dc.subject | SYSTEM | - |
dc.subject | MICRODIALYSIS | - |
dc.title | Focused Ultrasound Modulates the Level of Cortical Neurotransmitters: Potential as a New Functional Brain Mapping Technique | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Byoung-Kyong | - |
dc.contributor.affiliatedAuthor | Park, Shinsuk | - |
dc.identifier.doi | 10.1002/ima.20284 | - |
dc.identifier.scopusid | 2-s2.0-79955882735 | - |
dc.identifier.wosid | 000291155100014 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, v.21, no.2, pp.232 - 240 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 232 | - |
dc.citation.endPage | 240 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Imaging Science & Photographic Technology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Electrical & Electronic | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Imaging Science & Photographic Technology | - |
dc.subject.keywordPlus | TRANSCRANIAL MAGNETIC STIMULATION | - |
dc.subject.keywordPlus | MEDIATED INHIBITION | - |
dc.subject.keywordPlus | DOPAMINE RELEASE | - |
dc.subject.keywordPlus | CHLORAL HYDRATE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | TRYPTOPHAN | - |
dc.subject.keywordPlus | DORSAL | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | MICRODIALYSIS | - |
dc.subject.keywordAuthor | ultrasound | - |
dc.subject.keywordAuthor | sonication | - |
dc.subject.keywordAuthor | microdialysis | - |
dc.subject.keywordAuthor | high-performance liquid chromatography | - |
dc.subject.keywordAuthor | neuromodulation | - |
dc.subject.keywordAuthor | dopamine | - |
dc.subject.keywordAuthor | serotonin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.