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Focused Ultrasound Modulates the Level of Cortical Neurotransmitters: Potential as a New Functional Brain Mapping Technique

Authors
Min, Byoung-KyongYang, Po SongBohlke, MarkPark, ShinsukVago, David R.Maher, Timothy J.Yoo, Seung-Schik
Issue Date
2011
Publisher
WILEY
Keywords
ultrasound; sonication; microdialysis; high-performance liquid chromatography; neuromodulation; dopamine; serotonin
Citation
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, v.21, no.2, pp.232 - 240
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
Volume
21
Number
2
Start Page
232
End Page
240
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/114939
DOI
10.1002/ima.20284
ISSN
0899-9457
Abstract
Regional modulation of the level of cortical neurotransmitters in the brain would serve as a new functional brain mapping technique to interrogate the neurochemical actions of the brain. We investigated the utility of the application of low-intensity, pulsed sonication of focused ultrasound (FUS) to the brain to modulate the extracellular level of dopamine (DA) and serotonin (5-HT). FUS was delivered to the thalamic areas of rats, and extracellular DA and 5-HT were sampled from the frontal lobe using the microdialysis technique. The concentration changes of the sampled DA and 5-HT were measured through high-performance liquid chromatography. We observed a significant increase of the extracellular concentrations of DA and 5-HT in the FUS-treated group as compared with those in the unsonicated group. Our results provide the first direct evidence that FUS sonication alters the level of extracellular concentration of these monoamine neurotransmitters and has a potential modulatory effect on their local release, uptake, or degradation. Our findings suggest that the pulsed application of FUS offers new perspectives for a possible noninvasive modulation of neurotransmitters and may have diagnostic as well as therapeutic implications for DA/5-HT-mediated neurological and psychiatric disorders. (C) 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 232-240, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ima.20284
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