Inhibitory Effect of Pomegranate on Intestinal Sodium Dependent Glucose Uptake
DC Field | Value | Language |
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dc.contributor.author | Kim, Hye Kyung | - |
dc.contributor.author | Baek, Soon-Sun | - |
dc.contributor.author | Cho, Hong-Yon | - |
dc.date.accessioned | 2021-09-07T21:29:41Z | - |
dc.date.available | 2021-09-07T21:29:41Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0192-415X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114944 | - |
dc.description.abstract | Intestinal glucose uptake is mainly performed by its specific transporters, SGLT1 and GLUTs expressed in the intestinal epithelial cells. By using Caco-2 cells and 2-NBDG, we observed that intestinal glucose uptake was markedly inhibited by pomegranate (Punica granatum L, PG) among 200 screened edible Korean plants. The effects of the PG extract on Na+-dependent glucose uptake were further evaluated using brush border membrane vesicles (BBMV) obtained from the mouse small intestine. PG inhibited Na+-dependent glucose uptake with the IC50 value of 424 mu g/ml. The SGLT1 protein expression was dose dependently down regulated with PG treatment in Caco-2 cells. We next assessed the antihyperglycemic effect of PG in streptozotocin (STZ)-induced diabetic mice. Administration of PG (800 mg/kg) to STZ mice for four weeks improved postprandial glucose regulation. Furthermore, elevated Na+-dependent glucose uptake by BBMV isolated from STZ mice was normalized by PG treratment. These results suggest that PG could play a role in controlling the dietary glucose absorption at the intestinal tract by decreasing SGLT1 expression, and may contribute to blood glucose homeostasis in the diabetic condition. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WORLD SCIENTIFIC PUBL CO PTE LTD | - |
dc.subject | BORDER-MEMBRANE-VESICLES | - |
dc.subject | BRUSH-BORDER | - |
dc.subject | CHLOROGENIC ACID | - |
dc.subject | EXPRESSION | - |
dc.subject | TRANSPORTER | - |
dc.subject | HYPERGLYCEMIA | - |
dc.subject | COMPOUND | - |
dc.subject | REVERSES | - |
dc.subject | TARGETS | - |
dc.subject | SGLT1 | - |
dc.title | Inhibitory Effect of Pomegranate on Intestinal Sodium Dependent Glucose Uptake | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Hong-Yon | - |
dc.identifier.doi | 10.1142/S0192415X11009378 | - |
dc.identifier.scopusid | 2-s2.0-80052641592 | - |
dc.identifier.wosid | 000294613000014 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CHINESE MEDICINE, v.39, no.5, pp.1015 - 1027 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CHINESE MEDICINE | - |
dc.citation.title | AMERICAN JOURNAL OF CHINESE MEDICINE | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1015 | - |
dc.citation.endPage | 1027 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | BORDER-MEMBRANE-VESICLES | - |
dc.subject.keywordPlus | BRUSH-BORDER | - |
dc.subject.keywordPlus | CHLOROGENIC ACID | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSPORTER | - |
dc.subject.keywordPlus | HYPERGLYCEMIA | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | REVERSES | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | SGLT1 | - |
dc.subject.keywordAuthor | Pomegranate | - |
dc.subject.keywordAuthor | Na+-Dependent Glucose Uptake | - |
dc.subject.keywordAuthor | 2-NBDG | - |
dc.subject.keywordAuthor | Brush Border Membrane Vesicle | - |
dc.subject.keywordAuthor | Caco-2 Cell | - |
dc.subject.keywordAuthor | Streptozotocin-Induced Diabetic Mice | - |
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