Inhibitory Effect of Pomegranate on Intestinal Sodium Dependent Glucose Uptake
- Authors
- Kim, Hye Kyung; Baek, Soon-Sun; Cho, Hong-Yon
- Issue Date
- 2011
- Publisher
- WORLD SCIENTIFIC PUBL CO PTE LTD
- Keywords
- Pomegranate; Na+-Dependent Glucose Uptake; 2-NBDG; Brush Border Membrane Vesicle; Caco-2 Cell; Streptozotocin-Induced Diabetic Mice
- Citation
- AMERICAN JOURNAL OF CHINESE MEDICINE, v.39, no.5, pp.1015 - 1027
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF CHINESE MEDICINE
- Volume
- 39
- Number
- 5
- Start Page
- 1015
- End Page
- 1027
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/114944
- DOI
- 10.1142/S0192415X11009378
- ISSN
- 0192-415X
- Abstract
- Intestinal glucose uptake is mainly performed by its specific transporters, SGLT1 and GLUTs expressed in the intestinal epithelial cells. By using Caco-2 cells and 2-NBDG, we observed that intestinal glucose uptake was markedly inhibited by pomegranate (Punica granatum L, PG) among 200 screened edible Korean plants. The effects of the PG extract on Na+-dependent glucose uptake were further evaluated using brush border membrane vesicles (BBMV) obtained from the mouse small intestine. PG inhibited Na+-dependent glucose uptake with the IC50 value of 424 mu g/ml. The SGLT1 protein expression was dose dependently down regulated with PG treatment in Caco-2 cells. We next assessed the antihyperglycemic effect of PG in streptozotocin (STZ)-induced diabetic mice. Administration of PG (800 mg/kg) to STZ mice for four weeks improved postprandial glucose regulation. Furthermore, elevated Na+-dependent glucose uptake by BBMV isolated from STZ mice was normalized by PG treratment. These results suggest that PG could play a role in controlling the dietary glucose absorption at the intestinal tract by decreasing SGLT1 expression, and may contribute to blood glucose homeostasis in the diabetic condition.
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Collections - College of Science and Technology > Department of Food and Biotechnology > 1. Journal Articles
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