Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea. emergence of a novel OXA-182
- Authors
- Kim, Chang-Ki; Lee, Yangsoon; Lee, Hyukmin; Woo, Gun-Jo; Song, Wonkeun; Kim, Mi-Na; Lee, Wee-Gyo; Jeong, Seok Hoon; Lee, Kyungwon; Chong, Yunsop
- Issue Date
- Dec-2010
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- OXA carbapenemase; OXA-182; Metallo-beta-lactamase; Acinetobacter; baumannu; Acinetobacter genomospecies; Korea
- Citation
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v.68, no.4, pp.432 - 438
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Volume
- 68
- Number
- 4
- Start Page
- 432
- End Page
- 438
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115144
- DOI
- 10.1016/j.diagmicrobio.2010.07.014
- ISSN
- 0732-8893
- Abstract
- Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-beta-lactamase (MBL)-producing isolates bla(OXA) 23-like and ISAbal-asssociated bla(OXA) (51)-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannu isolates, respectively A novel bla(OXA) 182 was detected in 12 IPM-NS A baumannu isolates Twelve out of 14 MBL-producing isolates were non-baumannu Acinetobacter A baumannu isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannu Acinetobacter isolates with MBL Identical pulsed- field gel electrophoresis patterns were observed in 89% of A baumannu isolates with bla(OXA) 23-like gene In conclusion, extremely rapid increase of IPM-NS A baumannu in previous Korean studies was mainly due to clonal spread of OXA-(23)producing A baumannu isolates A novel OXA-182 emerged in Korea (C) 2010 Elsevier Inc All rights reserved
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