In vivo tumor suppression activity by T cell-specific T-bet restoration
- Authors
- Lee, Kihyun; Min, Hyun Jung; Jang, Eun Jung; Hong, Jeong-Ho; Hwang, Eun Sook
- Issue Date
- 1-Nov-2010
- Publisher
- WILEY
- Keywords
- T-bet; Th cell; IFN gamma; tumor development; metastatic melanoma
- Citation
- INTERNATIONAL JOURNAL OF CANCER, v.127, no.9, pp.2129 - 2137
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF CANCER
- Volume
- 127
- Number
- 9
- Start Page
- 2129
- End Page
- 2137
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115345
- DOI
- 10.1002/ijc.25238
- ISSN
- 0020-7136
- Abstract
- T-box-containing protein expressed in T cells (T-bet) is a master transcription factor for the development of interferon (IFN) gamma-producing T helper 1 (Th1) cells, and also functions in other immune cells including natural killer (NK), cytotoxic T lymphocytes and dendritic cells. T-bet-deficient mice increased susceptibility to viral infection and tumor development due to the defective functions of immune cells. T-bet is known to play a key role in NK-mediated antimetastatic response; however, it remains to be characterized whether T-bet is essential for in vivo tumor suppression mediated by T cells. Here, we have investigated in vivo tumor suppression effect of T-bet-restored T cells using T cell-specific and inducible T-bet transgenic mice generated in a T-bet-deficient background. T-bet-null mice increased susceptibility to tumor development, whereas induction of T cell-specific T-bet expression upon melanoma cell injection substantially suppressed tumor development by inducing IFN gamma production in T cells and tumor cell apoptosis. Late induction of T-bet expression in tumor-bearing mice produced comparable amounts of IFN gamma with control and, significantly decreased tumor volume. In addition, increased melanoma lung metastasis in T-bet-deficient mice was strikingly inhibited by T-bet restoration in T cells. Intravenous injection of activated Th1 cells, not T-bet-null Th1 cells, attenuated metastatic melanoma progression, in addition, restoration of T-bet in T-bet-null Th1 cells certainly retrieved antimetastatic activity. These results suggest that T-bet expression in T cells is crucial for the control of tumor development and antimetastatic activity.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.