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Core/Shell Nanoparticles for pH-Sensitive Delivery of Doxorubicin

Authors
Oh, Keun SangUm, Yun SikLee, Jin HoCho, Sun HangLee, Kyung EunHan, Sung SikKim, DongminYuk, Soon Hong
Issue Date
Oct-2010
Publisher
AMER SCIENTIFIC PUBLISHERS
Keywords
Core/Shell Nanoparticles with Drug-Loaded Lipid Cores; Lecithin; Pluronics; pH-Sensitive Release of Anticancer Drug; Doxorubicin
Citation
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.10, no.10, pp.6967 - 6971
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume
10
Number
10
Start Page
6967
End Page
6971
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115602
DOI
10.1166/jnn.2010.2986
ISSN
1533-4880
Abstract
Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.
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College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles

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