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Core/Shell Nanoparticles for pH-Sensitive Delivery of Doxorubicin
- Authors
- Oh, Keun Sang; Um, Yun Sik; Lee, Jin Ho; Cho, Sun Hang; Lee, Kyung Eun; Han, Sung Sik; Kim, Dongmin; Yuk, Soon Hong
- Issue Date
- Oct-2010
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Core/Shell Nanoparticles with Drug-Loaded Lipid Cores; Lecithin; Pluronics; pH-Sensitive Release of Anticancer Drug; Doxorubicin
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.10, no.10, pp.6967 - 6971
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 10
- Number
- 10
- Start Page
- 6967
- End Page
- 6971
- ISSN
- 1533-4880
- Abstract
- Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.
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Related Researcher
- Yuk, Soon Hong
- College of Pharmacy (Department of Pharmaceutical Science)