Rationally Designed Fluorescence Turn-On Sensors: A New Design Strategy Based on Orbital Control
- Authors
- Jung, Hyo Sung; Ko, Kyoung Chul; Lee, Jae Hong; Kim, Sang Hoon; Bhuniya, Sankarprasad; Lee, Jin Yong; Kim, Youngmee; Kim, Sung Jin; Kim, Jong Seung
- Issue Date
- 20-9월-2010
- Publisher
- AMER CHEMICAL SOC
- Citation
- INORGANIC CHEMISTRY, v.49, no.18, pp.8552 - 8557
- Indexed
- SCIE
SCOPUS
- Journal Title
- INORGANIC CHEMISTRY
- Volume
- 49
- Number
- 18
- Start Page
- 8552
- End Page
- 8557
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115669
- DOI
- 10.1021/ic101165k
- ISSN
- 0020-1669
- Abstract
- Herein, we explore a new strategy in the chemo-sensor field for fluorescence amplification upon binding with metal ions based on controlled participation of the nitrogen lone pair orbital. The basic architecture of the sensor entails a fluorophore, the sp(2) hybridized nitrogen lone pair (-C=N-), and a chelator site referred to as the control part. Though nonplanar and nonfluorescent, compound IC1 achieved pseudo planarity from binding with Zn2+ as indicated by the increased fluorescence signal. Its other analogue (IC2) is also planar, and unlike IC1-Zn2+ was fluorescent with a lack of binding affinity to metal ions. The time-dependent density functional theory (TDDFT) calculations revealed that the fluorescence amplification was due to the blocking of the nitrogen lone pair orbital; unlikely geometrical rearrangements were insignificant. This could indicate a breakthrough concept in the future design of fluorescent turn-on sensors.
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