Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials
- Authors
- Jung, Ki-Young; Cho, Jae-Wook; Joo, Eun Yeon; Kim, Sun Hwa; Choi, Kyung Mook; Chin, Juhee; Park, Kun-Woo; Hong, Seung Bong
- Issue Date
- 9월-2010
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Topiramate; Cognitive function; Event-related potential (ERP); Standardised low-resolution; electromagnetic tomography (sLORETA); Source localisation
- Citation
- CLINICAL NEUROPHYSIOLOGY, v.121, no.9, pp.1494 - 1501
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL NEUROPHYSIOLOGY
- Volume
- 121
- Number
- 9
- Start Page
- 1494
- End Page
- 1501
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115746
- DOI
- 10.1016/j.clinph.2010.03.013
- ISSN
- 1388-2457
- Abstract
- Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n = 18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n = 13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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