Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy
- Authors
- Ko, S-H; Kwon, H-S; Yu, J-M; Baik, S-H; Park, I-B; Lee, J-H; Ko, K-S; Noh, J-H; Kim, D-S; Kim, C-H; Mok, J-O; Park, T-S; Son, H-S; Cha, B-Y
- Issue Date
- 9월-2010
- Publisher
- WILEY-BLACKWELL
- Keywords
- diabetic complication; painful diabetic neuropathy; Type 2 diabetes mellitus
- Citation
- DIABETIC MEDICINE, v.27, no.9, pp.1033 - 1040
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETIC MEDICINE
- Volume
- 27
- Number
- 9
- Start Page
- 1033
- End Page
- 1040
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115782
- DOI
- 10.1111/j.1464-5491.2010.03054.x
- ISSN
- 0742-3071
- Abstract
- Aims This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy. Methods An open, randomized, comparative study was conducted. Subjects with painful symmetric neuropathy in the lower limbs and mean pain-intensity score >= 4 on a numeric rating scale were eligible. Subjects were randomized to receive either tramadol (37.5 mg)/acetaminophen (325 mg) or gabapentin (300 mg) for 6 weeks. After 2 weeks of the titration period (1200 mg/day for gabapentin and three tablets/day for T/A), the doses were maintained if the pain was relieved. The primary efficacy outcome was a reduction in pain intensity. Secondary measures evaluated a pain relief scale, a Brief Pain Inventory, a 36-item Short Form Health Survey, average pain intensity and sleep disturbance. Results One hundred and sixty-three subjects (T/A 79; gabapentin 84) were included. At the final visit, the mean doses were 1575 mg/day for gabapentin and 4.22 tablets/day for T/A. Both groups were similar in terms of baseline pain intensity (mean intensity: T/A 6.7 +/- 1.6; gabapentin 6.3 +/- 1.6, P = 0.168). At the final visit, the mean reductions in pain intensity were similar in both groups (T/A -3.1 +/- 2.0; gabapentin -2.7 +/- 2.1, P = 0.744). Both groups had similar improvements in every Short Form Health Survey category and Brief Pain Inventory subcategory, and in the mean pain relief scores. Conclusion This study suggests that the T/A combination treatment is as effective as gabapentin in the treatment of painful diabetic neuropathy in patients with Type 2 diabetes.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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