Direct Synthesis of Pyrazolo[5,1-alpha]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation
- Authors
- Choi, Young Lok; Lee, Hyuk; Kim, Bum Tae; Choi, Kihang; Heo, Jung-Nyoung
- Issue Date
- 8월-2010
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- C-H activation; direct arylation; palladium; pyrazoles
- Citation
- ADVANCED SYNTHESIS & CATALYSIS, v.352, no.11-12, pp.2041 - 2049
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED SYNTHESIS & CATALYSIS
- Volume
- 352
- Number
- 11-12
- Start Page
- 2041
- End Page
- 2049
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115946
- DOI
- 10.1002/adsc.201000260
- ISSN
- 1615-4150
- Abstract
- An efficient. direct synthesis of pyrazolo-[5.1-alpha]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl)pyrazoles has been developed The use of lithium chloride (LICI) was found to be essential in these reactions, to suppress further C H bond activation at the C-3 position of pyrazolo[5,1-alpha]isoindole, when C-3 is unsubstituted This protocol can be applied to the synthesis of a pyrazolo(5,1-alpha]isoqumnoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-alpha]isoindole using seciuential intra- and intermolecular C-H bond activation
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Science > Department of Chemistry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.