G protein beta 3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome
- Authors
- Lee, H. -J.; Lee, S. -Y.; Choi, J. E.; Kim, J. H.; Sung, I. -K.; Park, H. S.; Jin, C. J.
- Issue Date
- 7월-2010
- Publisher
- WILEY
- Keywords
- G protein; irritable bowel syndrome; poly-morphism; Rome III criteria
- Citation
- NEUROGASTROENTEROLOGY AND MOTILITY, v.22, no.7, pp.758 - 763
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROGASTROENTEROLOGY AND MOTILITY
- Volume
- 22
- Number
- 7
- Start Page
- 758
- End Page
- 763
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116144
- DOI
- 10.1111/j.1365-2982.2010.01496.x
- ISSN
- 1350-1925
- Abstract
- Background The association between irritable bowel syndrome (IBS) based on Rome III criteria and G protein beta 3 subunit (GNB3), interleukin (IL)-10, and tumor necrosis factor (TNF)-alpha gene polymorphisms is uncertain. Methods Case and control subjects were recruited from Korean visitors to the Health Promotion Center and Digestive Disease Center for gastrointestinal endoscopy. G protein beta 3 subunit, IL-10, and TNF-alpha gene polymorphisms were genotyped using a polymerase chain reaction-based method. Multifactor dimensionality reduction (MDR) analysis was used to assess gene-gene interactions. Key Results Genotype and allele frequencies of GNB3 showed marginal significance between the healthy controls and IBS patients (chi 2 = 5.92, P = 0.052; chi 2 = 3.76, P = 0.053). G protein beta 3 subunit T allele was more strongly correlated with IBS with constipation (12 of constipation-dominant type and 31 of mixed type) than with 51 diarrhea-dominant type and 88 normal subjects (chi 2 = 13.91, P = 0.008). Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05). Conclusions & Inferences The results suggest that GNB3 825T allele might be associated with IBS with constipation in Koreans.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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