Intake of Fish and n-3 Fatty Acids and Future Risk of Metabolic Syndrome
- Authors
- Baik, Inkyung; Abbott, Robert D.; Curb, J. David; Shin, Chol
- Issue Date
- 7월-2010
- Publisher
- AMER DIETETIC ASSOC
- Citation
- JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, v.110, no.7, pp.1018 - 1026
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
- Volume
- 110
- Number
- 7
- Start Page
- 1018
- End Page
- 1026
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116204
- DOI
- 10.1016/j.jada.2010.04.013
- ISSN
- 0002-8223
- Abstract
- Background Whether or not fish and n-3 fatty acid intake is associated with the metabolic syndrome risk has not been carefully evaluated. This study investigated the effect of fish and n-3 fatty acid intake on the incidence of metabolic syndrome and on the individual risk factors for the syndrome. Methods A population-based prospective cohort study included 3,504 male and female Koreans aged 40 to 69 years from the Korean Genome Epidemiology Study. At the beginning of follow-up, all individuals were free of metabolic syndrome and known cardiovascular disease. Each participant completed a food frequency questionnaire. Incident cases of metabolic syndrome were identified by biennial health examinations during a follow-up period between April 17, 2003, and November 17, 2006. Pooled logistic regression analysis was applied to obtain an odds ratio (OR) of metabolic syndrome with its 95% confidence interval (CI) for fish or n-3 fatty acid intake. Results After controlling for potential cardiovascular risk factors, multivariate OR for metabolic syndrome was 0.43 (95% CI 0.23 to 0.83) for men who ate fish daily when compared with those eating fish less than once a week. Similarly, metabolic syndrome risk was halved for men in the top decile of n-3 fatty acid intake when compared with those in the bottom decile (OR 0.53, 95% CI 0.28 to 0.99). In particular, fish intake was significantly associated with triglyceride level and high-density lipoprotein cholesterol level among the metabolic syndrome components. For women, apparent associations were not observed between fish intake or n-3 fatty acid intake and metabolic syndrome risk. Conclusions In a prospective study, high consumption of fish and n-3 fatty acids was significantly associated with a lower risk of metabolic syndrome among men, but not among women. Whether or not encouraging fish intake can help prevent the development of metabolic syndrome warrants further studies. J Am Diet Assoc. 2010;110:1018-1026.
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