Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study
- Authors
- Choo, Jina; Ueshima, Hirotsugu; Curb, J. David; Shin, Chol; Evans, Rhobert W.; El-Saed, Aiman; Kadowaki, Takashi; Okamura, Tomonori; Nakata, Katsumi; Otake, Teruo; Miura, Katsuyuki; Abbott, Robert D.; Sutton-Tyrrell, Kim; Edmundowicz, Daniel; Kuller, Lewis H.; Sekikawa, Akira
- Issue Date
- 1-5월-2010
- Publisher
- OXFORD UNIV PRESS
- Citation
- AMERICAN JOURNAL OF CLINICAL NUTRITION, v.91, no.5, pp.1195 - 1203
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF CLINICAL NUTRITION
- Volume
- 91
- Number
- 5
- Start Page
- 1195
- End Page
- 1203
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116470
- DOI
- 10.3945/ajcn.2009.28500
- ISSN
- 0002-9165
- Abstract
- Background: The associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain. Objective: We aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL. Design: We conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids. Results: Serum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA. Conclusions: At the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at clinicaltrials.gov as NCT00069797. Am J Clin Nutr 2010; 91: 1195-203.
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Collections - College of Nursing > Department of Nursing > 1. Journal Articles
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