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Overexpression of ethionine resistance gene for maximized production of S-adenosylmethionine in Saccharomyces cerevisiae sake kyokai No. 6
- Authors
- Lee, Sang-Woo; Park, Bu-Soo; Choi, Eun-Sil; Oh, Min-Kyu
- Issue Date
- Mar-2010
- Publisher
- KOREAN INSTITUTE CHEMICAL ENGINEERS
- Keywords
- S-adenosyl-L-methionine; Saccharomyces cerevisiae sake; Metabolic Engineering
- Citation
- KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.27, no.2, pp.587 - 589
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF CHEMICAL ENGINEERING
- Volume
- 27
- Number
- 2
- Start Page
- 587
- End Page
- 589
- ISSN
- 0256-1115
- Abstract
- In our previous work, we developed an auxotrophic mutant of Saccharomyces cerevisiae sake kyokai No. 6 strain for the selection of recombinant DNA. Sake yeast can accumulate high amount of S-adenosylmethionine (SAM) that is effective for treating depression, Alzheimer's disease and so on. In this work, we further introduced SAM2 gene and ERC1, a frame-shift mutant of YHR032w, to maximize the production of S-adenosylmethionine in S. cerevisiae sake K6. The recombinant strain accumulated SAM about half of its dry cell weight.
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