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Overexpression of ethionine resistance gene for maximized production of S-adenosylmethionine in Saccharomyces cerevisiae sake kyokai No. 6

Authors
Lee, Sang-WooPark, Bu-SooChoi, Eun-SilOh, Min-Kyu
Issue Date
3월-2010
Publisher
KOREAN INSTITUTE CHEMICAL ENGINEERS
Keywords
S-adenosyl-L-methionine; Saccharomyces cerevisiae sake; Metabolic Engineering
Citation
KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.27, no.2, pp.587 - 589
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume
27
Number
2
Start Page
587
End Page
589
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116886
DOI
10.1007/s11814-010-0100-3
ISSN
0256-1115
Abstract
In our previous work, we developed an auxotrophic mutant of Saccharomyces cerevisiae sake kyokai No. 6 strain for the selection of recombinant DNA. Sake yeast can accumulate high amount of S-adenosylmethionine (SAM) that is effective for treating depression, Alzheimer's disease and so on. In this work, we further introduced SAM2 gene and ERC1, a frame-shift mutant of YHR032w, to maximize the production of S-adenosylmethionine in S. cerevisiae sake K6. The recombinant strain accumulated SAM about half of its dry cell weight.
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