A Lipid-Soluble Red Ginseng Extract Inhibits the Growth of Human Lung Tumor Xenografts in Nude Mice
- Authors
- Lee, Sung Dong; Park, Song-Kyu; Lee, Eun Sil; Kim, Hwan Mook; Lee, Chang Woo; Lee, Kiho; Lee, Ki Hoon; Kang, Moo Rim; Lee, Kwang Seung; Lee, Junsoo; Hwang, Woo Ik; Kim, Dong Chung
- Issue Date
- 2월-2010
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- anticancer effect; human tumor xenograft; lipid-soluble ginseng extract; oral administration
- Citation
- JOURNAL OF MEDICINAL FOOD, v.13, no.1, pp.1 - 5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 13
- Number
- 1
- Start Page
- 1
- End Page
- 5
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/117101
- DOI
- 10.1089/jmf.2009.1142
- ISSN
- 1096-620X
- Abstract
- Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0 g/kg/day were 18.9% (P<.05), 60.0% (P<.001), and 67.5% (P<.001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
- College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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