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Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived NeuronsIdentification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons

Other Titles
Identification of Differentially Expressed Genes in Human Mesenchymal Stem Cell-Derived Neurons
Authors
Ji Hye Heo조경진최달웅김성욱
Issue Date
2010
Publisher
한국독성학회
Keywords
Mesenchymal stem cells; Neuron; Differentially expressed genes
Citation
한국독성학회지, v.26, no.1, pp.15 - 19
Indexed
SCOPUS
KCI
Journal Title
한국독성학회지
Volume
26
Number
1
Start Page
15
End Page
19
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/117587
ISSN
1976-8257
Abstract
Mesenchymal stem cells (MSCs) have greater potential for immediate clinical and toxicological applications,due to their ability to self-renew, proliferate, and differentiate into a variety of cell types. To identify novel candidate genes that were specifically expressed during transdifferentiation of human MSCs to neuronal cells, we performed a differential expression analysis with random priming approach using annealing control primer-based differential display reverse transcription-polymerase chain reaction approach. We identified genes for acyl-CoA thioesterase, tissue inhibitor of metalloproteinases-1, brain glycogen phosphorylase,ubiquitin C-terminal hydrolase and aldehyde reductase were up-regualted, whereas genes for transgelin and heparan sulfate proteoglycan were down-regulated in MSC-derived neurons. These differentially expressed genes may have potential role in regulation of neurogenesis. This study could be applied to environmental toxicology in the field of testing the toxicity of a chemical or a physical agent.
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