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Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-dionesSynthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-diones
- Other Titles
- Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H- 2,6-diazacyclopenta[b]anthracene-5,10-diones
- Issue Date
- 2010
- Publisher
- 대한약학회
- Keywords
- Cytotoxic activity; Diazacyclopenta[b]anthracene-5; 10-diones
- Citation
- Archives of Pharmacal Research, v.33, no.5, pp.663 - 667
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Archives of Pharmacal Research
- Volume
- 33
- Number
- 5
- Start Page
- 663
- End Page
- 667
- ISSN
- 0253-6269
- Abstract
- A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicinresistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line.
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Related Researcher
- Lee, Ki ho
- College of Pharmacy (Department of Pharmaceutical Science)