Anti-diabetic activities of Kocat-D1 in 3T3-L1 adipocytes and C57BL/KsJ-db/db mice
DC Field | Value | Language |
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dc.contributor.author | Yang, J.-H. | - |
dc.contributor.author | Won, H.-J. | - |
dc.contributor.author | Park, H.-Y. | - |
dc.contributor.author | Nam, M.-H. | - |
dc.contributor.author | Lee, H.-S. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kim, J.-T. | - |
dc.contributor.author | Lee, K.-W. | - |
dc.date.accessioned | 2021-09-08T09:00:43Z | - |
dc.date.available | 2021-09-08T09:00:43Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1226-3311 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118243 | - |
dc.description.abstract | This study investigated anti-diabetic activity of Kocat-D1, which is a currently used traditional medicine for treatment of diabetes in Shandong, China. Insulin sensitizing activity was observed in a cell-based glucose uptake assay using 3T3-L1 adipocytes. The treatment of 0.2 mg/mL of hot water extract of Kocat-D1 with 0.2 nM insulin was associated with a significant increasing in glucose uptake (165.0±0.7%) over the treatment of 0.2 nM insulin. C57BL/KsJ-db/db mice (8 weeks of age) were separated into 3 groups: normal control (control, db/ mice untreated), diabetic control (DM control, db/db mice untreated), Kocat-D1 (db/db mice treated with Kocat-D1 extract 350 mg/kg/day). After 16 weeks of treatment, body weight and total diet intake of Kocat-D1 group were significantly lower than DM control groups. Blood glucose levels of the Kocat-D1 group (14.7±1.4 mmol/L) were significantly lower compared to the DM control group (27.1±0.2 mmol/L). Furthermore, insulin level was significantly increased in the Kocat-D1 group (0.17±0.02 ng/mL) compared with the DM control group (0.05±0.02 ng/mL). The glomeruli in kidney was stained using periodic acid-shiff base (PAS) for confirming collagen accumulation. The glomeruli in kidney of Kocat-D1 group had significantly reduced PAS-positive compared with that of DM control. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | Mus | - |
dc.title | Anti-diabetic activities of Kocat-D1 in 3T3-L1 adipocytes and C57BL/KsJ-db/db mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, K.-W. | - |
dc.identifier.doi | 10.3746/jkfn.2010.39.5.692 | - |
dc.identifier.scopusid | 2-s2.0-77957746506 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Food Science and Nutrition, v.39, no.5, pp.692 - 698 | - |
dc.relation.isPartOf | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.title | Journal of the Korean Society of Food Science and Nutrition | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 692 | - |
dc.citation.endPage | 698 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001445758 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | Mus | - |
dc.subject.keywordAuthor | 3T3-L1 | - |
dc.subject.keywordAuthor | Anti-diabetes | - |
dc.subject.keywordAuthor | C57BL/KsJ-db/db mice | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Kocat-D1 | - |
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