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Inhibitors of nitric oxide production from Artemisia princeps

Authors
Li, D.Han, X.H.Hong, S.S.Lee, C.Lee, M.S.Lee, D.Lee, M.K.Hwang, B.Y.
Issue Date
2010
Keywords
Artemisia princeps; Compositae; Nitric oxide production inhibitor; Sesquiterpene lactone
Citation
Natural Product Sciences, v.16, no.3, pp.143 - 147
Indexed
SCOPUS
KCI
Journal Title
Natural Product Sciences
Volume
16
Number
3
Start Page
143
End Page
147
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118318
ISSN
1226-3907
Abstract
The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.
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