The Biological Monitoring of Urinary 1-hydroxypyrene by PAH Exposure Among Smokers
- Authors
- Lee, K. H.; Byeon, S. H.
- Issue Date
- 2010
- Publisher
- SPRINGER INTERNATIONAL PUBLISHING AG
- Keywords
- Biomarker; Polycyclic aromatic hydrocarbons; 1-hydroxypyrene; Cigarette smoking
- Citation
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, v.4, no.3, pp.439 - 442
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH
- Volume
- 4
- Number
- 3
- Start Page
- 439
- End Page
- 442
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118508
- ISSN
- 1735-6865
- Abstract
- This study examines changes in the urinary 1-hydroxypyrene (1-OHP) concentration as a polycyclic aromatic hydrocarbon (PAH) metabolite related to smoking among eight volunteers. The study subjects consisted of 8 participants (2 smokers, 4 ex-smokers and 2 non-smokers; mean age 23, range 21 24 years old) in a smoking cessation program. Three urine samples were collected each week for 4 weeks from each participant to give a total of 96 urine samples. None of the participants smoked during the study period. Levels of urinary 1-OHP, as an internal dose marker of smoke containing PAHs, were measured by high performance liquid chromatography (HPLC) fluorescence detector. Urinary 1-OHP levels in the ex-smokers were decreased during the 4 weeks study period, due to ambient sources of PAH exposure. Thus, smoking cessation was only expected to result in reduction of urinary 1-OHP. Urinary 1-OHP levels were significantly correlated with the amounts of cigarettes smoked, as assessed by the questionnaire (Spearman's correlation coefficient, r=0.23, P=0.03). This study suggested that urinary 1-OHP can be a potentially useful biomarker of smoke.
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