Blood Eicosapentaenoic Acid and Docosahexaenoic Acid as Predictors of All-Cause Mortality in Patients With Acute Myocardial Infarction - Data From Infarction Prognosis Study (IPS) Registry -
- Authors
- Lee, Sang-Hak; Shin, Min-Jeong; Kim, Jung-Sun; Ko, Young-Guk; Kang, Seok-Min; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik; Shim, Won-Heum; Cho, Seung-Yun; Manabe, Ichiro; Ha, Jong-Won
- Issue Date
- Dec-2009
- Publisher
- JAPANESE CIRCULATION SOC
- Keywords
- Death; Docosahexaenoic acid; Eicosapentaenoic acid; Myocardial infarction; omega-3 fatty acids
- Citation
- CIRCULATION JOURNAL, v.73, no.12, pp.2250 - 2257
- Indexed
- SCIE
SCOPUS
- Journal Title
- CIRCULATION JOURNAL
- Volume
- 73
- Number
- 12
- Start Page
- 2250
- End Page
- 2257
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118771
- DOI
- 10.1253/circj.CJ-09-0327
- ISSN
- 1346-9843
- Abstract
- Background: Although omega-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases. their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males;, mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29 P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients. (Circ J 2009; 73: 2250-2257)
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