Association Between Tumor Necrosis Factor alpha 308G/A Polymorphism and Increased Proinflammatory Cytokine Release After Cardiac Surgery With Cardiopulmonary Bypass in the Korean Population
- Authors
- Yoon, Seung Zhoo; Jang, In-Jin; Choi, Yoon Ji; Kang, Mae Hwa; Lim, Hye Ja; Lim, Young Jin; Lee, Hye Won; Chang, Seong Ho; Yoon, Suk Min
- Issue Date
- 10월-2009
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Keywords
- cardiopulmonary bypass; cytokine; morbidity; polymorphism; tumor necrosis factor alpha
- Citation
- JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, v.23, no.5, pp.646 - 650
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
- Volume
- 23
- Number
- 5
- Start Page
- 646
- End Page
- 650
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119236
- DOI
- 10.1053/j.jvca.2009.03.004
- ISSN
- 1053-0770
- Abstract
- Objectives: The G-308A polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene has been suggested to be linked to high TNF promoter activity in in vitro studies. However, there have been some controversies in in vivo studies. This study investigated whether A allele at TNF-308 site is associated with (1) the changes in plasma cytokine levels during and after cardiopulmonary bypass (CPB) and (2) an increased incidence of pulmonary morbidity after CPB. Design: Prospective and observational investigation. Setting: A university hospital, single institution. Participants: Patients scheduled for cardiac surgery with CPB. Intervention: TNF genotype was determined by the real-time polymerase chain reaction method. IL-6 and TNF-alpha levels were measured by enzyme-linked immunosorbent assay at the following time points: T1, before initiation of CPB; T2, 30 minutes of CPB; T3, 30 minutes after CPB; T4, 2 hours after CPB; and T5, 24 hours after CPB. The oxygen index, serum creatinine level, 24-hour blood loss, intubation time, and length of intensive care unit (ICU) stay were examined. Measurements and Main Results: The levels of TNF-alpha in group A (TNF-308GA/AA, n = 25) were higher at T3, T4, and T5 than group G (TNF-308GG, n = 225). The levels of IL-6 showed no statistical difference. The oxygenation index, serum creatinine level, 24-hour blood loss, intubation time, and length of ICU stay showed no statistical difference. Conclusions: TNF G-308A polymorphism may be associated with excess TNF-alpha secretion in this study and may not be associated with excess IL-6 secretion and postoperative morbidity after CPB. (C) 2009 Elsevier Inc. All rights reserved
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