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Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT2A Receptor
- Authors
- Shin, Eun-Joo; Jeong, Ji Hoon; Chung, Yoon Hee; Kim, Tae-Woo; Shin, Chan Young; Kim, Won-Ki; Ko, Kwang-Ho; Kim, Hyoung-Chun
- Issue Date
- 7월-2009
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
- Keywords
- kainic acid; genetically epilepsy-prone rat; wet dog shake
- Citation
- JOURNAL OF PHARMACOLOGICAL SCIENCES, v.110, no.3, pp.401 - 404
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PHARMACOLOGICAL SCIENCES
- Volume
- 110
- Number
- 3
- Start Page
- 401
- End Page
- 404
- ISSN
- 1347-8613
- Abstract
- Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results Suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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