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New types of potential BNCT agents, o-carboranyl aminoalcohols
- Authors
- Lee, Chai-Ho; Jin, Guo Fan; Joung, Jung Gun; Lee, Jong-Dae; Ban, Hyun Seung; Nakamura, Hiroyuki; Cho, Jung-Keun; Kang, Sang Ook
- Issue Date
- 17-6월-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Low cytotoxicity; Water solubility; Boron neutron capture therapy; Boron accumulation; o-Carboranylphenol derivatives
- Citation
- TETRAHEDRON LETTERS, v.50, no.24, pp.2960 - 2963
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 50
- Number
- 24
- Start Page
- 2960
- End Page
- 2963
- ISSN
- 0040-4039
- Abstract
- o-Carboranyl aminoalcohols were synthesized using a standard Mannich reaction, and were tested for their anticancer properties using an in vitro test for CT26 cancer cells. The polar periphery of the aminoalcohols benefited from the high boron uptake in CT26 cancer cells with low toxicity, indicating their potential as BNCT agents. (C) 2009 Elsevier Ltd. All rights reserved.
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