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Bioactive triterpenoids from Callistemon lanceolatus
- Authors
- Jeong, Wonsik; Hong, Seong Su; Kim, Nahyun; Yang, Young Taek; Shin, Yu Su; Lee, Chul; Hwang, Bang Yeon; Lee, Dongho
- Issue Date
- Jun-2009
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Callistemon lanceolatus; Myrtaceae; Triterpenoids; Betulinic acid 3-O-caffeate; NO production inhibitor
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.32, no.6, pp.845 - 849
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 32
- Number
- 6
- Start Page
- 845
- End Page
- 849
- ISSN
- 0253-6269
- Abstract
- A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 mu M.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology