Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population
- Authors
- Choi, Hyo Seon; Lee, Youngin; Park, Kyong Hwa; Sung, Jae Sook; Lee, Jong-Eun; Shin, Eun-Soon; Ryu, Jeong-Seon; Kim, Yeul Hong
- Issue Date
- 5월-2009
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- cyclin-dependent kinase 5 (CDK5); lung cancer; single-nucleotide polymorphism
- Citation
- JOURNAL OF HUMAN GENETICS, v.54, no.5, pp.298 - 303
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HUMAN GENETICS
- Volume
- 54
- Number
- 5
- Start Page
- 298
- End Page
- 303
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120089
- DOI
- 10.1038/jhg.2009.29
- ISSN
- 1434-5161
- Abstract
- Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. For example, a recent study detected overexpression of the CDK5 gene in non-small-cell lung cancer. Therefore, in order to explore the association of the CDK5 gene with lung cancer risk in a Korean population, the genotypes of the CDK5 promoter region were determined in 407 lung cancer patients and 402 normal participants. The result showed that the -904 G>A genotype affected susceptibility to lung cancer risk (odd ratios (OR)=1.53, 95% confidence interval (CI)=1.02-2.32). Furthermore, subsequent haplotype analysis of three single-nucleotide polymorphism (SNP) regions suggested that the A-G-C haplotype was associated with a higher overall risk of lung cancer (OR=1.59, 95% CI=1.16-2.18). These results suggest that CDK5 promoter polymorphisms contribute to the genetic susceptibility to lung cancer in the Korean population. Journal of Human Genetics (2009) 54, 298-303; doi:10.1038/jhg.2009.29; published online 3 April 2009
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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