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O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors
- Authors
- Lim, Kihong; Chang, Hyo-Ihl
- Issue Date
- 13-Mar-2009
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Elf-1; O-GlcNAc; Pem; Sp1
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.380, no.3, pp.569 - 574
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 380
- Number
- 3
- Start Page
- 569
- End Page
- 574
- ISSN
- 0006-291X
- Abstract
- The novel protein modification, O-linked N-acetylglucosamine (O-GlcNAc), plays ail important role in various aspects of cell regulation. Although most of nuclear transcription regulatory factors are modified by O-GlcNAc, O-GlcNAc effects oil transcription remain largely undefined yet. In this Study, we show that O-GlcNAc inhibits a physical interaction between Sp1 and Elf-1 transcription factors, and negatively regulates transcription of placenta and embryonic expression oncofetal protein gone (Pem). These findings Suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor. (C) 2009 Elsevier Inc. All rights reserved.
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