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Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-Derived Mesenchymal Stem Cells
- Issue Date
- 10-Mar-2009
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- drug delivery systems; structure; supports; surfaces; tissue engineering
- Citation
- MACROMOLECULAR BIOSCIENCE, v.9, no.3, pp.221 - 229
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 9
- Number
- 3
- Start Page
- 221
- End Page
- 229
- ISSN
- 1616-5187
- Abstract
- Two chondrogenic factors, Dex and TGF-beta 1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta 1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II Collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-beta 1.
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