Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1
- Authors
- Lim, Kihong; Chang, Hyo-Ihl
- Issue Date
- 4-Feb-2009
- Publisher
- WILEY
- Keywords
- O-GlcNAc; Oct1; Sp1; U2 snRNA
- Citation
- FEBS LETTERS, v.583, no.3, pp.512 - 520
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 583
- Number
- 3
- Start Page
- 512
- End Page
- 520
- ISSN
- 0014-5793
- Abstract
- Sp1 is a ubiquitous transcription factor that is modified by multiple O-linked N-acetylglucosamines (O-GlcNAc). Previously, O-GlcNAcylation of a specific site of Sp1 was shown to inhibit Sp1 transcriptional activity. Yet, how O-GlcNAc on other modi. cation sites affects Sp1 function and how O-GlcNAcylation of Sp1 affects the transcriptional regulation of a target gene remains unknown. Here we show that O-GlcNAc within the second serine/threonine-rich region of Sp1 interrupts a known interaction between Sp1 and Oct1, and inhibits the cooperative activation of the U2 snRNA gene by Sp1 and Oct1.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.