Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils
- Authors
- Ko, Il-Gyu; Shin, Mal-Soon; Kim, Bo-Kyun; Kim, Sung-Eun; Sung, Yun-Hee; Kim, Tae-Soo; Shin, Min-Chul; Cho, Han-Jin; Kim, Sin-Chul; Kim, Sang-Hoon; Kim, Khae-Hawn; Shin, Dong-Hoon; Kim, Chang-Ju
- Issue Date
- 2월-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cerebral ischemia; Phosphodiesterase-5 inhibitor; Tadalafil; Short-term memory; cGMP level; Apoptosis; Cell proliferation
- Citation
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, v.91, no.4, pp.629 - 635
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Volume
- 91
- Number
- 4
- Start Page
- 629
- End Page
- 635
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120661
- DOI
- 10.1016/j.pbb.2008.10.009
- ISSN
- 0091-3057
- Abstract
- Cerebral ischemia resulting from transient or permanent cerebral artery occlusion leads to neuronal cell death, and eventually causes neurological impairments. Tadalafil (Cialis (R)) is a long-acting phosphodiesterase type-5 (PDE-5) inhibitor used to treat erectile dysfunction. The therapeutic effects of PDE-5 inhibitors on chronic obstructive pulmonary disease, prostate hyperplasia, hypertension, and coronary heart disease have been reported. The present study investigated the effects of tadalafil on short-term memory, cyclic guanosine monophosphate (cGMP) level, apoptotic neuronal cell death, and cell proliferation in the hippocampus following transient global ischemia in gerbils. For this study, a step-down avoidance task. cGMP assay, terminal deoxynucleotidyl transferase-mediated cl nick end labeling assay, and immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine were performed. The results revealed that ischemic injury increased apoptotic neuronal cell death in the hippocampal CA1 region, impaired short-term memory, and decreased cGMP level. Ischemic injury enhanced cell proliferation in the hippocampal dentate gyrus. Tadalafil treatment improved short-term memory by suppressing ischemia-induced apoptotic neuronal cell death in the hippocampal CA1 region, and decreased cGMP level. Also, tadalafil suppressed the ischemia-induced increase in cell proliferation in the hippocampal dentate gyrus. We showed that tadalafil can overcome ischemia-induced apoptotic neuronal cell death, thus facilitates recovery following ischemic cerebral injury. (c) 2008 Elsevier Inc. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- College of Science and Technology > Department of Food and Biotechnology > 1. Journal Articles
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