Chemical exchange of hydroxyl protons in quercetin measured by pulsed field gradient NMR
DC Field | Value | Language |
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dc.contributor.author | Hong, Y. -S. | - |
dc.contributor.author | Hong, K. S. | - |
dc.contributor.author | Cho, J. -H. | - |
dc.contributor.author | Volkov, V. I. | - |
dc.contributor.author | Lee, C. -H. | - |
dc.date.accessioned | 2021-09-08T20:22:10Z | - |
dc.date.available | 2021-09-08T20:22:10Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0937-9347 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120687 | - |
dc.description.abstract | The diffusion behavior of hydroxyl protons (OH) in quercetin in 100% DMSO-d(6) (deuterium dimethylsulfoxide) and a 90% DMSO-d(6) solution containing 10% H2O was investigated with 600 MHz H-1 pulsed field gradient (PFG) nuclear magnetic resonance (NMR). Only resonances of the 5-hydroxyl protons (OH5) were well resolved in NMR spectra of quercetin for all solutions under study. This phenomenon is explained by the intramolecular hydrogen bonding between OH5 protons and the 4-carbonyl oxygen (CO4). During diffusion experiments, the OH5 protons showed a biexponential diffusion decay, indicating an exchange process with water. As water content in the solvents increased, the lifetime (tau (q)) of the OH5 protons decreased from 96.7 +/- 10.0 ms in 100% DMSO-d(6) to 14.3 +/- 1.4 ms in the 90% DMSO-d(6) solution containing 10% H2O, indicating an increase in the exchange rate (k (q) = l/tau (q)) of the OH5 protons. This study demonstrates that the diffusion approach with PFG-NMR is much faster and easier for estimating the short lifetime or fast exchange rate of hydroxyl protons in quercetin. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER WIEN | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | DIFFUSION | - |
dc.subject | FLAVONOIDS | - |
dc.subject | COMPLEXES | - |
dc.subject | ALUMINUM | - |
dc.subject | METABOLISM | - |
dc.subject | DEPENDENCE | - |
dc.subject | MEMBRANE | - |
dc.subject | MODEL | - |
dc.title | Chemical exchange of hydroxyl protons in quercetin measured by pulsed field gradient NMR | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Y. -S. | - |
dc.contributor.affiliatedAuthor | Lee, C. -H. | - |
dc.identifier.doi | 10.1007/s00723-008-0160-2 | - |
dc.identifier.scopusid | 2-s2.0-65449145616 | - |
dc.identifier.wosid | 000265497600006 | - |
dc.identifier.bibliographicCitation | APPLIED MAGNETIC RESONANCE, v.35, no.2, pp.261 - 270 | - |
dc.relation.isPartOf | APPLIED MAGNETIC RESONANCE | - |
dc.citation.title | APPLIED MAGNETIC RESONANCE | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 261 | - |
dc.citation.endPage | 270 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | ALUMINUM | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | DEPENDENCE | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MODEL | - |
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