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Orexin-A increases cell surface expression of AMPA receptors in the striatum

Authors
Shin, Hyun SungCho, Hyeong SeokSung, Ki-WugYoon, Bong-June
Issue Date
16-Jan-2009
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Orexin-A; AMPA receptor; Synaptic plasticity; Drug addiction
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.378, no.3, pp.409 - 413
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
378
Number
3
Start Page
409
End Page
413
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120746
DOI
10.1016/j.bbrc.2008.11.051
ISSN
0006-291X
Abstract
Accumulating evidence Suggests that orexin signaling is involved in reward and motivation circuit functions. However, the underlying mechanisms are not yet fully understood. Here, we show that orexin-A potentiates AMPAR-mediated synaptic transmission in the striatum, possibly by regulating the surface expression of AMPARs. Primary culture of striatal neurons revealed increased surface expression of AMPARs following orexin-A treatment. The increase in surface-expressed AMPARs induced by orexin-A treatment was dependent on both ERK activation and the presence of extracellular Ca2+. In the cortico-striatal synapses of rat brain slices, orexin-A bath-application caused a delayed increase in the AMPAR/NMDAR EPSC ratio, suggesting that orexin-A sets in motion a series of events that lead to functional alterations in the striatal circuits. Our findings provide a potential link between the activation of orexin signaling in the striatum in response to addictive substances and neural adaptations in the reward circuitry that may mediate the long-lasting addiction-related behaviors. (C) 2008 Elsevier Inc. All rights reserved.
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