Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation
DC Field | Value | Language |
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dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Jung, Myung Gu | - |
dc.contributor.author | Lee, Yoo-Hyun | - |
dc.contributor.author | Yoon, Joo Chun | - |
dc.contributor.author | Kwon, Seung Hyun | - |
dc.contributor.author | Kang, Hee-Bum | - |
dc.contributor.author | Kim, Mi Jeong | - |
dc.contributor.author | Cha, Jeong-Heon | - |
dc.contributor.author | Kim, Young Jun | - |
dc.contributor.author | Jun, Woo Jin | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Yoon, Ho-Geun | - |
dc.date.accessioned | 2021-09-08T20:48:12Z | - |
dc.date.available | 2021-09-08T20:48:12Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-01-15 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120752 | - |
dc.description.abstract | Because the p300/CBP-mediated hyperacetylation of RelA (p65) is critical for nuclear factor-kappa B (NF-kappa B) activation, the attenuation of p65 acetylation is a potential molecular target for the prevention of chronic inflammation. During our ongoing screening study to identify natural compounds with histone acetyltransferase inhibitor (HATi) activity, we identified epigallocatechin-3-gallate (EGCG) as a novel HATi with global specificity for the majority of HAT enzymes but with no activity toward epigenetic enzymes including HDAC, SIRT1, and HMTase. At a dose of 100 mu mol/L, EGCG abrogates p300-induced p65 acetylation in vitro and in vivo, increases the level of cytosolic I kappa B alpha, and suppresses tumor necrosis factor a (TNF alpha)-induced NF-kappa B activation. We also showed that EGCG prevents TNF alpha-induced p65 translocation to the nucleus, confirming that hyperacetylation is critical for NF-kappa B translocation as well as activity. Furthermore, EGCG treatment inhibited the acetylation of p65 and the expression of NF-kappa B target genes in response to diverse stimuli. Finally, EGCG reduced the binding of p300 to the promoter region of interleukin-6 gene with an increased recruitment of HDAC3, which highlights the importance of the balance between HATS and historic deacetylases in the NF-kappa B-mediated inflammatory signaling pathway. Importantly, EGCG at 50 mu mol/L dose completely blocks EBV infection-induced cytokine expression and subsequently the EBV-induced B lymphocyte transformation. These results show the crucial role of acetylation in the development of inflammatory-related diseases. [Cancer Res 2009;69(2):583-92] | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | TEA-DERIVED POLYPHENOL | - |
dc.subject | GREEN TEA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CHRONIC INFLAMMATION | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | ACTIVATION | - |
dc.subject | BINDING | - |
dc.title | Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-08-2442 | - |
dc.identifier.scopusid | 2-s2.0-58349094740 | - |
dc.identifier.wosid | 000262582900027 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.69, no.2, pp.583 - 592 | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 69 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 583 | - |
dc.citation.endPage | 592 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TEA-DERIVED POLYPHENOL | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BINDING | - |
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