Combination chemotherapy of S-1 and taxanes in Korea
- Authors
- Kim, Yeul Hong; Kim, Hoon-Kyo
- Issue Date
- Jan-2009
- Publisher
- SPRINGER
- Keywords
- Gastric neoplasm; Docetaxel; Paclitaxel; S-1; Combination chemotherapy
- Citation
- GASTRIC CANCER, v.12, pp.31 - 37
- Indexed
- SCIE
SCOPUS
- Journal Title
- GASTRIC CANCER
- Volume
- 12
- Start Page
- 31
- End Page
- 37
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120816
- DOI
- 10.1007/s10120-008-0464-9
- ISSN
- 1436-3291
- Abstract
- Various combination treatments incorporating S-1 are undergoing clinical trials in Korea, especially combinations with taxane, oxaliplatin, or irinotecan. In a phase I study to estimate the maximum tolerated dose of docetaxel in combination with S-1 administered at a fixed dose of 40 mg/m(2) twice daily on days 1-14 of each 3-week cycle in patients with advanced gastric cancer, 60 mg/m(2) docetaxel was declared to be the maximum tolerated dose. A phase I/II study of the same schedule of combination chemotherapy with S-1 plus docetaxel reported doses of S-1/docetaxel of 40/75 mg/m(2) as the maximum tolerated dose. In a phase I study of S-1 plus weekly docetaxel, the patients received variable doses of docetaxel administered intravenously over 1 h on days 1 and 8 and S-1 administered on days 1-14 of each 3-week cycle. The maximum-tolerated doses of S-1 and docetaxel were determined to be 45 mg/m(2) and 35 mg/m(2) in this study. A phase I/II study of docetaxel plus S-1 combination chemotherapy from Korea reported a response rate of 43.3%. Also, a phase II study of paclitaxel plus S-1 as first-line therapy in patients with advanced or relapsed gastric cancer showed an overall response rate of 49%. The most frequent significant toxicities in combination chemotherapies with taxane plus S-1 were neutropenia and febrile neutropenia. However, nonhematological toxicities were mild to moderate. A taxane plus S-1 combination regimen could be a new standard regimen for advanced gastric cancer, given its significant activity and favorable toxicity pattern.
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