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Association Between Interleukin 1 Polymorphisms and Rheumatoid Arthritis Susceptibility: A Metaanalysis

Authors
Lee, Young HoJi, Jong DaeSong, Gwan Gyu
Issue Date
Jan-2009
Publisher
J RHEUMATOL PUBL CO
Keywords
INTERLEUKIN 1; GENETIC POLYMORPHISM; RHEUMATOID ARTHRITIS
Citation
JOURNAL OF RHEUMATOLOGY, v.36, no.1, pp.12 - 15
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF RHEUMATOLOGY
Volume
36
Number
1
Start Page
12
End Page
15
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120874
DOI
10.3899/jrheum.080450
ISSN
0315-162X
Abstract
Objective. To determine whether interleukin I (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and I Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988 p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European Populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. (First Release Nov 1 2008; J Rheumatol 2009:36:12-15; doi: 10.3899/jrheum.080450)
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