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Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis
- Issue Date
- 28-Nov-2008
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Angiogenesis; Apoptosis; Calpain 6; Endothelial cell; Ovarian carcinoma cell
- Citation
- CANCER LETTERS, v.271, no.2, pp.306 - 313
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER LETTERS
- Volume
- 271
- Number
- 2
- Start Page
- 306
- End Page
- 313
- ISSN
- 0304-3835
- Abstract
- Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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Related Researcher
- Chun, Tae hoon
- Department of Biotechnology