Effects of hydrophilic and lipophilic beta-sitosterol derivatives on cholesterol absorption and plasma cholesterol levels in rats
- Authors
- Chung, Dae-Won; Kim, Won-Dai; Noh, Seung Kwon; Dong, Mi-Sook
- Issue Date
- 13-Aug-2008
- Publisher
- AMER CHEMICAL SOC
- Keywords
- beta-sitosterol; hydrophilic derivative; lipophilic derivative; cholesterol absorption; plasma cholesterol level
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.56, no.15, pp.6665 - 6670
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 56
- Number
- 15
- Start Page
- 6665
- End Page
- 6670
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122861
- DOI
- 10.1021/jf8004405
- ISSN
- 0021-8561
- Abstract
- The effects of two phytosterol derivatives of beta-sitosterol, a lipophilic derivative (LPSS) and a hydrophilic derivative (HPSS), on cholesterol uptake and blood lipoprotein levels in rats were compared with those of beta-sitosterol. LPSS and HPSS have solubilities of up to 0.05 g/mL in edible oil and 0.15 g/mL in water at 25 degrees C, respectively. The intragastric administration of either 30 or 50 mg of phytosterols with 10 mg of [4-C-14]-cholesterol per kg of body weight once a day for 3 consecutive days reduced cholesterol uptake by approximately 30% compared to controls that received cholesterol alone. Feeding a cholesterol-enriched diet containing 1% or 3% beta-sitosterol, LPSS, or HPSS for 2 and 4 weeks resulted in lowered levels of total blood cholesterol and reduced the atherogenic index in all groups. These results indicate that LPSS and HPSS have comparable effects to beta-sitosterol in lowering blood cholesterol levels but they differ from beta-sitosterol in having a solubility advantage.
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