Tyrosinase inhibitor from the flowers of Impatiens balsamina
- Authors
- Lim, Young-Hee; Kim, In-Hwan; Seo, Jung-Ju; Kim, Jeong-Keun
- Issue Date
- 12월-2006
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- tyrosinase inhibitor; kaempferol; Impatiens balsamina; melanin
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.16, no.12, pp.1977 - 1983
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 16
- Number
- 12
- Start Page
- 1977
- End Page
- 1983
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123111
- ISSN
- 1017-7825
- Abstract
- Kaempferol was isolated and identified from the methanol extract of the flowers of Impatiens balsamina. Kaempferol showed inhibitory activity against mushroom tyrosinase with an ID50 of 0.042 mM. Inhibition kinetics, as determined using a Lineweaver-Burk plot, showed kaempferol to be a competitive inhibitor of mushroom tyrosinase with a K-i value of 0.011 mM. The lag phase of tyrosine hydroxylation catalyzed by mushroom tyrosinase clearly increased on increasing the concentration of kaempferol. In addition to its tyrosinase inhibiting activity, kaempferol strongly inhibited melanin production by Streptomyces bikiniensis, in a dose-dependent manner, without inhibiting cell growth. For comparative purposes, the tyrosinase inhibitory activity of kaempferol was also assayed versus quercetin, a positive standard.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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