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PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells

Authors
Jang, Chan HoLee, In AeHa, Young RanLim, JinkyuSung, Mi-KyungLee, Sung-JoonKim, Jong-Sang
Issue Date
Jul-2008
Publisher
TAYLOR & FRANCIS LTD
Keywords
phosphoglycerate kinase 1 (PGK1); oxidative stress; antioxidant; biomarker
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.72, no.7, pp.1799 - 1808
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
72
Number
7
Start Page
1799
End Page
1808
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123291
DOI
10.1271/bbb.80079
ISSN
0916-8451
Abstract
Few protein biomarkers for oxidative stress have been reported. In this study, we attempted to identify the proteins selectively overexpressed in human colon tumor cells by treating with hydrogen peroxide as oxidative stress. A proteomic analysis followed by western blotting showed that phosphoglycerate kinase 1 (PGK1) was induced by hydrogen peroxide in a dose-dependent manner, while its expression was suppressed by a co-treatment with delphinidin, a known antioxidant. Furthermore, several antioxidants, including alpha-tocopherol, butylated hydroxytoluene (BHT), and Trolox, also inhibited the PGK1 induction caused by hydrogen peroxide. The data suggest that PGK1 might be a potential protein biomarker of intracellular oxidative status.
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