The role of CD4(+)CD25(bright) regulatory T cells in the maintenance of pregnancy, premature rupture of membranes, and labor
- Authors
- Seol, Hyun-Joo; Oh, Min-Jeong; Lim, Ji-Eun; Jung, Nan-Hee; Yoon, Soo-Young; Kim, Hai-Joong
- Issue Date
- 30-Jun-2008
- Publisher
- YONSEI UNIV COLLEGE MEDICINE
- Keywords
- regulatory T cells; pregnancy; premature rupture of membranes
- Citation
- YONSEI MEDICAL JOURNAL, v.49, no.3, pp.366 - 371
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- YONSEI MEDICAL JOURNAL
- Volume
- 49
- Number
- 3
- Start Page
- 366
- End Page
- 371
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123348
- DOI
- 10.3349/ymj.2008.49.3.366
- ISSN
- 0513-5796
- Abstract
- Purpose: The aim of this study was to evaluate the changes of the regulatory T cell subset in peripheral blood caused by gestational age and premature rupture of membranes (PROM) with or without labor to verify the role of regulatory T cells in pregnancy. Patients and Methods: We investigated regulatory T cell distribution in the peripheral blood of pregnancies during the first trimester (group I, n = 2), the second trimester (group II, n = 12), and the third trimester without PROM and labor (group III, n = 15). In addition, we evaluated pregnancies in the third trimester complicated by PROM (group IV, n = 4) and labor with no complication by PROM (Group V, n = 5). Comparisons were made with non-pregnant controls (group VI, n = 4) using flow cytometry. Results: During uncomplicated pregnancy, the CD4(+)CD25(bright) regulatory T cell population decreased with advancing gestational age (group I = 3.35 +/- 0.47, group 11 = 2.91 +/- 1.44, group III = 2.81 +/- 1.36, group VI = 2.52 +/- 0.7 1, p = NS). When we compared group IV with group III and V to evaluate the changes of the regulatory T cells with PROM, the CD4(+)D25(bright) regulatory T cell population was significantly decreased in group IV compared to group III (p=0.001) and group V (p=0.026). Conclusion: The present results revealed that the regulatory T cell population increased in early pregnancy but decreased in pregnancies complicated by PROM, indicating that regulatory T cells might be related to the maintenance of pregnancy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.