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Hollow silica nanocontainers as drug delivery vehicles
- Authors
- Yang, Jaemoon; Lee, Jaewon; Kang, Jinyoung; Lee, Kwangyeol; Suh, Jin-Suck; Yoon, Ho-Geun; Huh, Yong-Min; Haam, Seungjoo
- Issue Date
- 1-4월-2008
- Publisher
- AMER CHEMICAL SOC
- Citation
- LANGMUIR, v.24, no.7, pp.3417 - 3421
- Indexed
- SCIE
SCOPUS
- Journal Title
- LANGMUIR
- Volume
- 24
- Number
- 7
- Start Page
- 3417
- End Page
- 3421
- ISSN
- 0743-7463
- Abstract
- Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
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