Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung CancerAssociation of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer
- Other Titles
- Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer
- Authors
- 김대식; 성재숙; 신은순; 유정선; 최인근; 박경화; 박용; 김의배; 박세종; 김열홍
- Issue Date
- 2008
- Publisher
- 대한암학회
- Keywords
- PIM-1; PIM; Single Nucleotide Polymorphism; SNP; Lung neoplasms; Oncogenes; Haplotypes
- Citation
- Cancer Research and Treatment, v.40, no.4, pp.190 - 196
- Indexed
- KCI
- Journal Title
- Cancer Research and Treatment
- Volume
- 40
- Number
- 4
- Start Page
- 190
- End Page
- 196
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125071
- ISSN
- 1598-2998
- Abstract
- Purpose: The expression of the PIM-1 gene, which is a
proto-oncogene that encodes a serine/threonine kinase,
is associated with multiple cellular functions such as proliferation,
differentiation, apoptosis and tumorigenesis. In
particular, several studies have reported that the PIM-1
gene is associated with the development of lymphoma,
leukemia and prostate cancer. Therefore, this study was
conducted to evaluate the association between the single
nucleotide polymorphisms in the PIM-1 gene and the
risk of lung cancer occurrence in the Korean population.
Materials and Methods: To evaluate the role of the
PIM-1 gene in the development of lung cancer, the genotypes
of the PIM-1 gene were determined in 408 lung
cancer patients and 410 normal subjects.
Results: We found that the T-C-T-C haplotypes of the
PIM-1 gene (−1196 T>C, IVS4 +55 T>C, IVS4 +1416
T>A and +3684 C>A) were associated with an increased risk of lung cancer [adjusted odds ratio (aOR): 3.98; 95%
CI: 1.24∼12.75, p-value: 0.020]. In particular, these haplotypes
showed an increased risk of lung cancer in males
(aOR: 5.67; 95% CI: 1.32∼24.30, p-value: 0.019) and
smokers (aOR: 7.82; 95% CI: 1.75∼34.98, p-value:
0.007).
Conclusions: The present results suggest that the
T-C-T-C haplotype of the PIM-1 gene could influence the
risk of developing smoking-related lung cancer in the
Korean population. Additional functional studies with an
larger sample sized analysis are warranted to reconfirm
our findings.
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