Psyllium husk combined with hydroxycitrate reduces body weight gain and body fat in diet-induced obese rats
- Authors
- Kang, Duk Ho; Jung, Eun Young; Chang, Un Jae; Bae, Song-Hwan; Suh, Hyung Joo
- Issue Date
- Jun-2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- body fat; psyllium husk; hydroxycitrate; plasma lipid; short-chain fatty acid; rat
- Citation
- NUTRITION RESEARCH, v.27, no.6, pp.349 - 355
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRITION RESEARCH
- Volume
- 27
- Number
- 6
- Start Page
- 349
- End Page
- 355
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125761
- DOI
- 10.1016/j.nutres.2007.04.010
- ISSN
- 0271-5317
- Abstract
- The fortified physiological activities of psyllium with hydroxycitrate (HCA) will promote the use of this mixture in making nutraceutical foods. Male Sprague-Dawley rats were fed high-fat diets containing fiber-free (, control), cellulose (F-control), psyllium husk (WF-1), and psyllium husk + HCA (WF-2) for 4 weeks. Weight gains in WF-2 were significantly lower than those of the control (P <.05). Relative weights of perirenal and epididymal fat in WF-2 were significantly lower than in the other groups (P <.05). The levels of feces bile acid and fat in WF-2 were significantly higher than in the other groups (P <.05). The levels of plasma triacylglycerol and HTR (high-density lipoprotein cholesterol/total cholesterol) in fiber-containing groups (F-control, WF-1 and WF-2) were significantly lower than in the control (P <.05). Especially, triacylglycerol was significantly lower in WF-2 than in WF-1 and F-control (P <.05). Dietary supplementation with psyllium increased the total short-chain fatty acid concentration (23.36 mu mol/L in WF-1 and 26.97 mu mol/L in WF-2), compared with F-control (18.97 mu mol/L) and control (10.92 umol/L) diets. The mixture of psyllium and HCA reduced both body weight gain and body fat in high fat-fed rats, suggesting efficacy as an antiobesity supplement. (C) 2007 Elsevier Inc. All rights reserved.
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