Pathological predictive factors for late recurrence of hepatocellular carcinoma in chronic liver disease
- Authors
- Nahm, Ji H.; Lee, Hye S.; Kim, Haeryoung; Yim, Sun Y.; Shin, Ji-hyun; Yoo, Jeong E.; Ahn, Sang H.; Choi, Jin S.; Lee, Ju-Seog; Park, Young N.
- Issue Date
- 7월-2021
- Publisher
- WILEY
- Keywords
- chronic hepatitis; cirrhosis; hepatocellular carcinoma; inflammation; nomogram; recurrence
- Citation
- LIVER INTERNATIONAL, v.41, no.7, pp.1662 - 1674
- Indexed
- SCIE
SCOPUS
- Journal Title
- LIVER INTERNATIONAL
- Volume
- 41
- Number
- 7
- Start Page
- 1662
- End Page
- 1674
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/127761
- DOI
- 10.1111/liv.14835
- ISSN
- 1478-3223
- Abstract
- Background & Aims Late recurrence of hepatocellular carcinoma (HCC) is regarded as de novo HCC from chronic hepatitis. This study investigated clinicopathological and molecular factors to develop a nomogram for predicting late HCC recurrence (>2 years after curative resection). Methods The training and validation cohorts included HCC patients with a major aetiology of hepatitis B who underwent curative resection. Clinicopathological features including lobular and porto-periportal inflammatory activity, fibrosis and liver cell change were evaluated. Proteins encoded by genes related to late recurrence were identified using a reverse phase protein array of 95 non-tumourous liver tissues. Immunoexpression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), plasminogen activator inhibitor-1, phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) and spleen tyrosine kinase (SYK) was measured. Results Late recurrence occurred in 74/402 (18%) and 47/243 (19%) in the training and validation cohorts respectively. Cirrhosis, moderate/severe lobular inflammatory activity, and expression of pSTAT3, pERK1/2, and SYK proteins correlated to the gene signature of hepatocyte injury and regeneration were independently associated with late recurrence, with odds ratios (95% confidence intervals) of 2.0 (1.2-3.3), 21.1 (4.3-102.7) and 6.0 (2.1-17.7) respectively (P .05 for all). A nomogram based on these variables (histological parameters and immunohistochemical marker combinations) showed high reliability in both the training and validation cohorts (Harrell's C index: 0.701 and 0.716; 95% confidence intervals: 0.64-0.76 and 0.64-0.79 respectively). Conclusions The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis (fibrosis) predicts late HCC recurrence.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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