Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study
- Authors
- Song, Juhyun; Park, Dae Won; Cha, Jae-hyung; Seok, Hyeri; Kim, Joo Yeong; Park, Jonghak; Cho, Hanjin
- Issue Date
- 12-5월-2021
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.11, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 11
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128035
- DOI
- 10.1038/s41598-021-89548-y
- ISSN
- 2045-2322
- Abstract
- We investigated association between epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients and clinical outcomes in Korea. This nationwide retrospective cohort study included 5621 discharged patients with COVID-19, extracted from the Korea Disease Control and Prevention Agency (KDCA) database. We compared clinical data between survivors (n=5387) and non-survivors (n=234). We used logistic regression analysis and Cox proportional hazards model to explore risk factors of death and fatal adverse outcomes. Increased odds ratio (OR) of mortality occurred with age (>= 60 years) [OR 11.685, 95% confidence interval (CI) 4.655-34.150, p<0.001], isolation period, dyspnoea, altered mentality, diabetes, malignancy, dementia, and intensive care unit (ICU) admission. The multivariable regression equation including all potential variables predicted mortality (AUC=0.979, 95% CI 0.964-0.993). Cox proportional hazards model showed increasing hazard ratio (HR) of mortality with dementia (HR 6.376, 95% CI 3.736-10.802, p<0.001), ICU admission (HR 4.233, 95% CI 2.661-6.734, p<0.001), age >= 60 years (HR 3.530, 95% CI 1.664-7.485, p=0.001), malignancy (HR 3.054, 95% CI 1.494-6.245, p=0.002), and dyspnoea (HR 1.823, 95% CI 1.125-2.954, p=0.015). Presence of dementia, ICU admission, age >= 60 years, malignancy, and dyspnoea could help clinicians identify COVID-19 patients with poor prognosis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.