Different Influence of Blood Pressure on New-Onset Atrial Fibrillation in Pre- and Postmenopausal Women A Nationwide Population-Based Study
- Authors
- Kim, Yun Gi; Han, Kyung-Do; Kim, Do Young; Choi, Yun Young; Choi, Ha Young; Roh, Seung-Young; Shim, Jaemin; Kim, Jin Seok; Choi, Jong-Il; Kim, Young-Hoon
- Issue Date
- 5월-2021
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- atrial fibrillation; blood pressure; hypertension; menopause; risk factors
- Citation
- HYPERTENSION, v.77, no.5, pp.1500 - 1509
- Indexed
- SCIE
SCOPUS
- Journal Title
- HYPERTENSION
- Volume
- 77
- Number
- 5
- Start Page
- 1500
- End Page
- 1509
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/128091
- DOI
- 10.1161/HYPERTENSIONAHA.120.16513
- ISSN
- 0194-911X
- Abstract
- The characteristics of hypertension in pre- and postmenopausal women are different. Hypertension is a known risk factor for new-onset atrial fibrillation (AF), but its interaction with the menopause state is not fully established. We investigated whether menopause influences the adverse impact of high blood pressure on new-onset AF using a nationwide population-based cohort in Korea. People who underwent both a national health check-up and national cancer screening program were included in this study. A total of 3 280 834 women were assessed with 23 781 070 person*year follow-up data. Menopause was observed in 1 439 161 women. The risk of new-onset AF and blood pressure showed a linear relationship in premenopausal women (P<0.001 for both systolic and diastolic blood pressure). The risk of new-onset AF was increased by 58.8% if systolic blood pressure was >= 160 mm Hg compared with the reference group (100 mm Hg <= systolic blood pressure <110 mm Hg; hazard ratio=1.588 [95% CI, 1.383-1.823]) in premenopause group. However, no consistent correlation was observed between blood pressure and the risk of new-onset AF in postmenopausal women. The increased risk of new-onset AF attributable to elevated blood pressure was more pronounced in patients not taking antihypertension medications (P for interaction <0.001). In conclusion, elevated blood pressure, especially systolic blood pressure, was a significant risk factor for new-onset AF in premenopausal women. Postmenopausal women showed a significantly attenuated association between blood pressure and the risk of new-onset AF. Elevated systolic blood pressure had a more profound impact on new-onset AF in women not taking medications for hypertension.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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