Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Guk | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Cho, Kyoungwon | - |
dc.contributor.author | Park, Sung Sun | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.date.accessioned | 2021-12-07T02:41:41Z | - |
dc.date.available | 2021-12-07T02:41:41Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2636-0772 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/129986 | - |
dc.description.abstract | The aim of this study was to investigate the effect of a mixture of multi-strain probiotics and prebiotics on loperamide-induced constipation in Sprague-Dawley rats. A multi-strain probiotics alone (loperamide-induced group with multi-strain probiotics mixture group; Lop-Pro) and a mixture of multi-strain probiotics and prebiotics (loperamide-induced group with multi-strain probiotics and prebiotics mixture group; Lop-Pro/Pre) were administered orally after inducing constipation. The fecal water content was significantly higher (by 42%) in the Lop-Pro/Pre group (33.5%) than in the loperamide-induced group (Lop) (23.7%) (p<0.05). The intestinal mucosal thickness, crypt cell area, and interstitial cells of Cajal area were significantly higher in the Lop-Pro/Pre group compared to the Lop group by 16.4%, 20.6%, and 42.3%, respectively. Additionally, the total short-chain fatty acid content was significantly increased in the Lop-Pro and Lop-Pro/Pre groups by 56.4% and 54.2%, respectively, compared with the Lop group. The Lop-Pro and Lop-Pro/Pre groups recovered loperamide-induced alteration in Bacteroidetes and Verrucomicrobia abundance among intestinal microbiota, whereas the Lop-Pro/Pre group recovered Akkermansia, Lactobacillus, Clostridium, Bacteroides, and Oscillibacter abundance. Moreover, the relative abundance of Oscillibacter and Clostridium was significantly different in the Lop-Pro/Pre group compared to the Lop group. Collectively, administration of synbiotics rather than multi-strain probiotics alone is effective in alleviating constipation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES | - |
dc.subject | IRRITABLE-BOWEL-SYNDROME | - |
dc.subject | CHILDHOOD CONSTIPATION | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | FUNCTIONAL CONSTIPATION | - |
dc.subject | INTERSTITIAL-CELLS | - |
dc.subject | DIETARY FIBER | - |
dc.subject | COLONIC MUCUS | - |
dc.subject | FATTY-ACIDS | - |
dc.subject | LACTOBACILLUS | - |
dc.subject | CAJAL | - |
dc.title | Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.5851/kosfa.2021.e17 | - |
dc.identifier.scopusid | 2-s2.0-85106599044 | - |
dc.identifier.wosid | 000652361400013 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE OF ANIMAL RESOURCES, v.41, no.3, pp.527 - 541 | - |
dc.relation.isPartOf | FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.title | FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 527 | - |
dc.citation.endPage | 541 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002710981 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | IRRITABLE-BOWEL-SYNDROME | - |
dc.subject.keywordPlus | CHILDHOOD CONSTIPATION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | FUNCTIONAL CONSTIPATION | - |
dc.subject.keywordPlus | INTERSTITIAL-CELLS | - |
dc.subject.keywordPlus | DIETARY FIBER | - |
dc.subject.keywordPlus | COLONIC MUCUS | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | LACTOBACILLUS | - |
dc.subject.keywordPlus | CAJAL | - |
dc.subject.keywordAuthor | constipation | - |
dc.subject.keywordAuthor | multi-strain probiotics | - |
dc.subject.keywordAuthor | loperamide | - |
dc.subject.keywordAuthor | microbiota | - |
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