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Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat

Authors
Kim, Min GukJo, KyungaeCho, KyoungwonPark, Sung SunSuh, Hyung JooHong, Ki-Bae
Issue Date
2021
Publisher
KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES
Keywords
constipation; multi-strain probiotics; loperamide; microbiota
Citation
FOOD SCIENCE OF ANIMAL RESOURCES, v.41, no.3, pp.527 - 541
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE OF ANIMAL RESOURCES
Volume
41
Number
3
Start Page
527
End Page
541
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/129986
DOI
10.5851/kosfa.2021.e17
ISSN
2636-0772
Abstract
The aim of this study was to investigate the effect of a mixture of multi-strain probiotics and prebiotics on loperamide-induced constipation in Sprague-Dawley rats. A multi-strain probiotics alone (loperamide-induced group with multi-strain probiotics mixture group; Lop-Pro) and a mixture of multi-strain probiotics and prebiotics (loperamide-induced group with multi-strain probiotics and prebiotics mixture group; Lop-Pro/Pre) were administered orally after inducing constipation. The fecal water content was significantly higher (by 42%) in the Lop-Pro/Pre group (33.5%) than in the loperamide-induced group (Lop) (23.7%) (p<0.05). The intestinal mucosal thickness, crypt cell area, and interstitial cells of Cajal area were significantly higher in the Lop-Pro/Pre group compared to the Lop group by 16.4%, 20.6%, and 42.3%, respectively. Additionally, the total short-chain fatty acid content was significantly increased in the Lop-Pro and Lop-Pro/Pre groups by 56.4% and 54.2%, respectively, compared with the Lop group. The Lop-Pro and Lop-Pro/Pre groups recovered loperamide-induced alteration in Bacteroidetes and Verrucomicrobia abundance among intestinal microbiota, whereas the Lop-Pro/Pre group recovered Akkermansia, Lactobacillus, Clostridium, Bacteroides, and Oscillibacter abundance. Moreover, the relative abundance of Oscillibacter and Clostridium was significantly different in the Lop-Pro/Pre group compared to the Lop group. Collectively, administration of synbiotics rather than multi-strain probiotics alone is effective in alleviating constipation.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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